Ammonium Chloride → HCID 178428432, compound

HRID 731037Notes

Reaction equation

HRID 731037 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([C:17]3[CH:26]=[CH:25][C:20]([O:21][CH2:22][C:23]#[N:24])=[CH:19][CH:18]=3)=[CH:14][CH:15]=2)[C:10]([CH3:27])=[C:9]1[CH3:28])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N-:29]=[N+:30]=[N-:31].[Na+].[NH4+].[Cl-]>CN(C=O)C>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([C:17]3[CH:18]=[CH:19][C:20]([O:21][CH2:22][C:23]4[NH:31][N:30]=[N:29][N:24]=4)=[CH:25][CH:26]=3)=[CH:14][CH:15]=2)[C:10]([CH3:27])=[C:9]1[CH3:28])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 68814203HCID 68814203, compound

Product 1

HCID 178428432HCID 178428432, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The desired product was prepared using a procedure similar to step 6 of example 3. Thus, [4-(1-benzyl-2,3-dimethyl-1H-indol-5-yl)-phenoxy]-acetonitrile (0.202 g, 0.551 mmol) was reacted with NaN3 (0.179 g, 2.756 mmol) and NH4Cl (0.147 g, 2.756 mmol) in DMF (5 ml) to give the product (0.176 g, 0.430 mmol, 78%) as a yellow solid, dec. 229-232° C.

Sources & evidence

ORD record
ord-7592f329a1e9445784fd7e4da19c94d7
Source dataset
uspto-grants-2009_09
Patent number
US07582773B2

Reaction notes

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