Aluminium lithium hydride → (1-Cyclopropyl-1H-indazol-5-yl) methanol

Participants

Reaction Steps

To a stirred solution of methyl 1-cyclopropyl-1H-indazole-5-carboxylate (400 mg, 1.8 mmol, step-1 of Example 28) in THF (15 mL) was added LiAlH4 (70 mg, 1.8 mmol) at 0° C. The reaction mixture was stirred for 1 hr at room temperature, and quenched with saturated aqueous NH4Cl (20 mL). The mixture was diluted with DCM (80 mL), dried over Na2SO4, filtered through a pad of Celite (registered trademark) the filtrate was concentrated to give 386 mg (quant.) of the titled compound as pale yellow oil.

Provenance & Evidence