反应详情

To a stirred solution of methyl 1-cyclopropyl-1H-indazole-5-carboxylate (400 mg, 1.8 mmol, step-1 of Example 28) in THF (15 mL) was added LiAlH4 (70 mg, 1.8 mmol) at 0° C. The reaction mixture was stirred for 1 hr at room temperature, and quenched with saturated aqueous NH4Cl (20 mL). The mixture was diluted with DCM (80 mL), dried over Na2SO4, filtered through a pad of Celite (registered trademark) the filtrate was concentrated to give 386 mg (quant.) of the titled compound as pale yellow oil.

1. customquenched with saturated aqueous NH4Cl (20 mL)
2. additionThe mixture was diluted with DCM (80 mL)
3. dry with materialdried over Na2SO4
4. filtrationfiltered through a pad of Celite (registered trademark) the filtrate
5. concentrationwas concentrated