Potassium Carbonate → HCID 68815874, compound

Participants

Reaction Steps

The desired product was prepared using a procedure similar to step 5 of example 3. Thus, 4-(1-methyl-3-pentyl-2-phenyl-1H-indol-5-yl)-phenol (0.173 g, 0.472 mmol) was reacted with K2CO3 (0.078 g, 0.566 mmol) and bromoacetonitrile (0.068 g, 0.566 mmol) in acetone (10 ml) to give the product (0.160 g, 0.392 mmol, 83%) as a white solid, mp 101-102° C. 1H NMR (DMSO-d6) δ 0.76 (t, J=7.0 Hz, 3H), 1.14-1.22 (m, 4H), 1.52-1.98 (m, 2H), 2.66 (t, J=7.5 Hz, 2H), 3.56 (s, 3H), 5.21 (s, 2H), 7.16 (d, J=8.9 Hz, 2H), 7.43-7.51 (m, 5H), 7.55 (t, J=7.2 Hz, 2H), 7.69 (d, J=8.9 Hz, 2H), 7.76 (d, J=1.1 Hz, 1H); [ESI(+)], m/z 409 (M+H)+.

Provenance & Evidence