Sodium Hydroxide → N,N-Diethyl-2-oxiranemethanamine

HRID 731142노트

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HRID 731142 반응식
[OH-].[Na+].Cl[CH2:4][CH:5]([OH:12])[CH2:6][N:7]([CH2:10][CH3:11])[CH2:8][CH3:9]>O>[CH2:6]([N:7]([CH2:10][CH3:11])[CH2:8][CH3:9])[CH:5]1[O:12][CH2:4]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 52988591-Chloro-3-(diethylamino)-2-propanol

생성물 1

HCID 95611N,N-Diethyl-2-oxiranemethanamine수율 76%

시약·촉매·용매 1

HCID 962Water용매2회

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온도
22.5 °C

실험 절차

A solution of sodium hydroxide (47.9 g, 1.2 mole) in 78 mL water was added 1-chloro-3-diethylamino-propan-2-ol. The resultant was stirred at 20-25° C. for 1 hour, diluted with 178 mL of water and extracted with ether twice. The combined ether solution was dried with solid potassium hydroxide and evaporated to give 135 g of crude product which was purified by fraction distillation to give pure glycidyldiethylamine (98 g, 76%) as an oil.

후처리

  1. extractionextracted with ether twice
  2. dry with materialThe combined ether solution was dried with solid potassium hydroxide
  3. customevaporated
  4. customto give 135 g of crude product which
  5. distillationwas purified by fraction distillation

출처 및 근거

ORD 기록
ord-e64deccf602b48ee9f1fecbbe37cd445
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07582756B2

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