Thionyl Chloride → 5-Bromo-1-chloro-2,3-dihydro-1H-indene

HRID 731181Notes

Reaction equation

HRID 731181 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:7](O)[CH2:6][CH2:5]2.S(Cl)([Cl:14])=O>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:7]([Cl:14])[CH2:6][CH2:5]2

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 134862995-bromo-2,3-dihydro-1H-inden-1-ol

Product 1

HCID 223495155-Bromo-1-chloro-2,3-dihydro-1H-indene

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 47.2 (11.1 mmol) and thionyl chloride (44 mmol) in DCM (20 mL) was stirred at room temperature overnight. After evaporation of solvent, 47.3 was obtained and it was used without further purification.

Workup

  1. customAfter evaporation of solvent
  2. custom47.3 was obtained
  3. customit was used without further purification

Sources & evidence

ORD record
ord-5026e2f771874f2087328fd253aa1a6f
Source dataset
uspto-grants-2009_09
Patent number
US07582803B2

Reaction notes

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