Trifluoroacetic acid → HCID 57835804, compound

HRID 731211Notes

Reaction equation

HRID 731211 reaction equation
C(O)(C(F)(F)F)=O.COC1C=CC(C[O:15][C:16]2[CH:21]=[CH:20][C:19]([CH:22]([C:36]3[CH2:40][CH2:39][O:38][N:37]=3)[CH2:23][C:24]([O:26]CC3C=CC(OC)=CC=3)=[O:25])=[CH:18][CH:17]=2)=CC=1>C(Cl)Cl>[O:38]1[CH2:39][CH2:40][C:36]([CH:22]([C:19]2[CH:18]=[CH:17][C:16]([OH:15])=[CH:21][CH:20]=2)[CH2:23][C:24]([OH:26])=[O:25])=[N:37]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57835744HCID 57835744, compound

Product 1

HCID 57835804HCID 57835804, compoundYield 101.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

TFA (1 mL) was added to 85.1 (100 mg) in DCM (1 mL). The mixture was stirred at room temperature for 40 hours. TFA and DCM were removed under vacuum, and the residue was treated with EtOH (50 mL). The insoluble solid was removed by filtration. The filtrate was concentrated to give 85.2 (50 mg), which was used in the next step without further purification. MS ESI (pos.) m/e: 236 (M+H).

Workup

  1. customTFA and DCM were removed under vacuum
  2. additionthe residue was treated with EtOH (50 mL)
  3. customThe insoluble solid was removed by filtration
  4. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-15ac2ab3b7ca47a3bb5fb584dc34601d
Source dataset
uspto-grants-2009_09
Patent number
US07582803B2

Reaction notes

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