1-Methylpiperazine → HCID 178473852, compound

HRID 731419Notes

Reaction equation

[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([N:10]([C@H:29]2[CH2:34][CH2:33][C@H:32]([CH3:35])[CH2:31][CH2:30]2)[C:11]([NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21](=[O:28])[N:22]3[CH2:27][CH2:26]C[CH2:24][CH2:23]3)=[CH:17][N:18]=2)=[O:12])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[C:36]([N:39]1CCC(N([C@H]2CC[C@H](C)CC2)C(=O)NC2SC(SCC(O)=O)=CN=2)CC1)(=O)C.CN1CCNCC1>>[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([N:10]([C@H:29]2[CH2:30][CH2:31][C@H:32]([CH3:35])[CH2:33][CH2:34]2)[C:11]([NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21]([N:22]3[CH2:27][CH2:26][N:39]([CH3:36])[CH2:24][CH2:23]3)=[O:28])=[CH:17][N:18]=2)=[O:12])[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

Participants

Reactant 3

HCID 531671-Methylpiperazine

HCID 178473850HCID 178473850, compound

HCID 178473853HCID 178473853, compound

Product 1

HCID 178473852HCID 178473852, compound

Procedure

Prepared in a similar manner to 1-(1-acetyl-piperidin-4-yl)-1-(trans-4-methyl-cyclohexyl)-3-[5-(2-oxo-2-piperidin-1-yl-ethylsulfanyl)-thiazol-2-yl]-urea using {2-[3-(1-acetyl-piperidin-4-yl)-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid and N-methylpiperazine.

Sources & evidence

ORD record: ord-54adacf4eb414166af7762102c2d85e0
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07582769B2

Reaction notes

Loading…