HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bis-(1H-imidazol-2-YL)-methanone → HCID 178473156, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bis-(1H-imidazol-2-YL)-methanone | HCID 5250894 | — |
| Reactant | Ethyl 2-(2-aminothiazol-5-ylthio)acetate | HCID 21455623 | — |
| Reactant | HCID 178495626 | HCID 178495626 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178473156 | HCID 178473156 | — |
Reaction Steps
A mixture of (2-amino-thiazol-5-ylsulfanyl)-acetic acid ethyl ester, carbonyl diimidazole (0.34 g) and 4-dimethylaminopyridine (12 mg) in dichloromethane (10 mL) and tetrahydrofuran (10 mL) was stirred at room temperature for 5 h. Cyclohexyl-(trans-4-methoxymethyl-cyclohexyl)-amine was added and the reaction stirred overnight at room temperature. Purification by flash chromatography gave {2-[3-cyclohexyl-3-(trans-4-methoxymethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582769B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-c9f1b3bfc9f1412b80451dc9f2fa5454 |
| Source note | uspto-grants-2009_09 |