反应详情

A mixture of (2-amino-thiazol-5-ylsulfanyl)-acetic acid ethyl ester, carbonyl diimidazole (0.34 g) and 4-dimethylaminopyridine (12 mg) in dichloromethane (10 mL) and tetrahydrofuran (10 mL) was stirred at room temperature for 5 h. Cyclohexyl-(trans-4-methoxymethyl-cyclohexyl)-amine was added and the reaction stirred overnight at room temperature. Purification by flash chromatography gave {2-[3-cyclohexyl-3-(trans-4-methoxymethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester.

1. stirringthe reaction stirred overnight at room temperature
2. customPurification by flash chromatography