HRID731462

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID19381486

N-Cyclohexyl-4-phenylcyclohexanamine

C18H27N

HCID57481427

Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoate

C9H14N2O2S2

结构：CC[C@H]1CC[C@H](N(C(=O)Nc2ncc(SCC(=O)O)s2)C2CCCC2)CC1

HCID178455810

未命名化合物

PRODUCTS

生成物

结构：CC(C)(Sc1cnc(NC(=O)N(C2CCCCC2)C2CCC(c3ccccc3)CC2)s1)C(=O)O

HCID57688203

未命名化合物

PROCEDURE

实验过程

Prepared in a similar manner to {2-[3-cyclopentyl-3-(trans-4-ethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid via cyclohexyl-(4-phenyl-cyclohexyl)-amine and 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f662987a6f5e4fda97ef74c293e7b8d1
来源数据集: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07582769B2
来源说明: uspto-grants-2009_09

反应 SMILES

C1(N([C@H]2CC[C@H](CC)CC2)C(=O)NC2SC(SC[C:16](O)=[O:17])=CN=2)CCCC1.[CH:28]1([NH:34][CH:35]2[CH2:40][CH2:39][CH:38]([C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)[CH2:37][CH2:36]2)[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1.C([O:49][C:50](=[O:61])[C:51]([S:54][C:55]1[S:59][C:58]([NH2:60])=[N:57][CH:56]=1)([CH3:53])[CH3:52])C>>[CH:28]1([N:34]([CH:35]2[CH2:36][CH2:37][CH:38]([C:41]3[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=3)[CH2:39][CH2:40]2)[C:16](=[O:17])[NH:60][C:58]2[S:59][C:55]([S:54][C:51]([CH3:53])([CH3:52])[C:50]([OH:49])=[O:61])=[CH:56][N:57]=2)[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]1