反应详情

温度

40 °C

An mixture of 1,1-carbonyldiimidazole (2 equiv), 5-amino-1,3,4-thiadiazole-2-sulfonic acid methylamide, cyclohexyl-(trans-4-methyl-cyclohexyl)-amine (1 equivalent) and DMAP (5 mol %) in THF-toluene (1:1) was heated for 16 h at 40° C. and then cooled to room temperature. The reaction mixture was concentrated in vacuo and the crude product was dissolved in MeCN and purified (HPLC method 1) to give the title compound.

1. temperaturecooled to room temperature
2. concentrationThe reaction mixture was concentrated in vacuo
3. dissolutionthe crude product was dissolved in MeCN
4. custompurified (HPLC method 1)