Water → 2-[[2-Amino-5-[[(2,3-difluorophenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-2-methyl-1,3-propanediol

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

The product from step (d) (1.5 g) was suspended in NMP (10 ml), then Hunigs base (1.5 ml) and 2-Amino-2-methylpropanediol (1.37 g) added. Reaction mixture heated to 110° C. under N2 for 4 hrs. A further aliquot of 2-Amino-2-methylpropanediol (0.685 g) was added and mixture heated at 110° C. for 5 hrs. Mixture poured in to water (400 ml) and solid was collected by filtration. Purified by column chromatography (EtOAc: Methanol (95:5)) to give 0.756 g of product. 42% yield.

Herkunft & Nachweise