Methanol → 2-[[5-[[(2,3-Difluorophenyl)methyl]thio]-2-methoxythiazolo[4,5-d]pyrimidin-7-yl]amino]-2-methyl-1,3-propanediol

Participants

Role	Name	HCID	Charge
Reactant	Methanol	HCID 887	—
Reactant	Water	HCID 962	—
Reactant	Potassium Hydroxide	HCID 14797	—
Reactant	2-[[2-Chloro-5-[[(2,3-difluorophenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-2-methyl-1,3-propanediol	HCID 69060196	—
Product	2-[[5-[[(2,3-Difluorophenyl)methyl]thio]-2-methoxythiazolo[4,5-d]pyrimidin-7-yl]amino]-2-methyl-1,3-propanediol	HCID 69060496	90%

Reaction Conditions

Temperature	50 °C

Reaction Steps

The product from step (f) (0.339 g) was suspended in methanol (32 ml). Potasium hydroxide (0.088 g) added and mixture stirred at 50° C. for 20 minutes. Neutralised with 2N HCl and solvents removed in vacuo to give an orange residue. Water added to remove inorganics and the yellow solid was collected by filtration to give 0.3 g of desired product. 90% yield.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07585867B2
Source dataset	uspto-grants-2009_09
ORD ID	ord-df1d178ec1554d3daf70f6b37933fb07
Source note	uspto-grants-2009_09