1-Benzyl-4-(2-fluorobenzyl)piperidin-4-ol → 4-[(2-Fluorophenyl)methyl]piperidin-4-ol

Participants

Reaction Steps

A solution of EXAMPLE 1A (39.0 g, 131 mmol) in ethyl acetate (500 mL) was treated with Pd/C (3.90 g), stirred under hydrogen atmosphere (60 psi) until the reaction was complete by TLC analysis, and filtered. The filtrate was concentrated to give a residue that was used without further purification. MS (ESI) m/e 210 (M+H)+.

Provenance & Evidence