1-Benzyl-4-(2-fluorobenzyl)piperidin-4-ol → 4-[(2-Fluorophenyl)methyl]piperidin-4-ol

HRID 731533Notes

Reaction equation

HRID 731533 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[F:22])([OH:14])[CH2:10][CH2:9]1)C1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[F:22][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[CH2:15][C:11]1([OH:14])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 1

HCID 127332241-Benzyl-4-(2-fluorobenzyl)piperidin-4-ol

Product 1

HCID 107271164-[(2-Fluorophenyl)methyl]piperidin-4-ol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of EXAMPLE 1A (39.0 g, 131 mmol) in ethyl acetate (500 mL) was treated with Pd/C (3.90 g), stirred under hydrogen atmosphere (60 psi) until the reaction was complete by TLC analysis, and filtered. The filtrate was concentrated to give a residue that was used without further purification. MS (ESI) m/e 210 (M+H)+.

Workup

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated
  3. customto give a residue that
  4. customwas used without further purification

Sources & evidence

ORD record
ord-97ab637cbf584715bd81be9ea37ab8fe
Source dataset
uspto-grants-2009_09
Patent number
US07585858B2

Reaction notes

Loading…