HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 178486599, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Fluoro-3-nitrobenzene-1-sulfonyl chloride | HCID 2782799 | — |
| Reactant | 4-(4-(2-Fluorobenzyl)-4-methoxy-1-piperidinyl)benzenecarboximidamide | HCID 59186657 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178486599 | HCID 178486599 | — |
Reaction Steps
A solution of EXAMPLE 1H (0.200 g, 0.587 mmol) in dichloromethane (5 mL) was treated with triethylamine (0.245 mL, 1.76 mmol) and 4-fluoro-3-nitrobenzenesulfonyl chloride (prepared according to the procedure described in U.S. patent applicaiton Ser. No. 09/957,256, 0.169 g, 0.704 mmol), stirred overnight, and concentrated. The residue was purified by silica gel chromatography eluting with 40% ethyl acetate in hexanes to provide the desired product. MS (ESI) m/e 543 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585858B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-d8aa57426c8b4d35a45dd28a919169a9 |
| Source note | uspto-grants-2009_09 |