HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-((4'-Chlorobiphenyl-2-yl)methyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-((4'-chlorobiphenyl-2-yl)methyl)piperazine-1-carboxylate | HCID 22662065 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-((4'-Chlorobiphenyl-2-yl)methyl)piperazine | HCID 17834423 | — |
Reaction Steps
A solution of EXAMPLE 22B (1.00 g, 2.59 mmol) in dioxane (20 mL) at room temperature was treated with 4N HCl in dioxane (19.4 mL, 77.7 mmol), stirred overnight. Solvent was removed under reduced pressure. The residue was further dried under vacuum and used for the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585858B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-92cba3769b3e498badbae76d68eb5b07 |
| Source note | uspto-grants-2009_09 |