Hydrochloric Acid → 1-((4'-Chlorobiphenyl-2-yl)methyl)piperazine

HRID 731557Notes

Reaction equation

HRID 731557 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[CH2:14][N:15]2[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]2)=[CH:4][CH:3]=1.Cl>O1CCOCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[CH2:14][N:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22662065Tert-butyl 4-((4'-chlorobiphenyl-2-yl)methyl)piperazine-1-carboxylate

Product 1

HCID 178344231-((4'-Chlorobiphenyl-2-yl)methyl)piperazine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of EXAMPLE 22B (1.00 g, 2.59 mmol) in dioxane (20 mL) at room temperature was treated with 4N HCl in dioxane (19.4 mL, 77.7 mmol), stirred overnight. Solvent was removed under reduced pressure. The residue was further dried under vacuum and used for the next step without further purification.

Workup

  1. customSolvent was removed under reduced pressure
  2. customThe residue was further dried under vacuum
  3. customused for the next step without further purification

Sources & evidence

ORD record
ord-92cba3769b3e498badbae76d68eb5b07
Source dataset
uspto-grants-2009_09
Patent number
US07585858B2

Reaction notes

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