反应详情

温度

115 °C

A solution of 1-(2-chloroethyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (3.84 g, 12.0 mmol) in DMF is treated with potassium phthalate (2.78 g, 15.0 mmol, heated at 115° C. for 16 h, cooled to room temperature, diluted with water and extracted with ethyl acetate. The combined extracts are washed with brine, dried over MgSO4 and concentrated in vacuo. The resultant residue is crystallized from CH2Cl2/hexane to afford the title compound as a white solid, 4.54 g, characterized by HNMR analysis.

1. temperaturecooled to room temperature
2. extractionextracted with ethyl acetate
3. washThe combined extracts are washed with brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated in vacuo
6. customThe resultant residue is crystallized from CH2Cl2/hexane