Trifluoroacetic acid → HCID 22663021, compound

HRID 731599Notes

Reaction equation

HRID 731599 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9]([N:12]1[C:20]2[CH:19]=[CH:18][N:17]=[CH:16][C:15]=2[C:14]([CH2:21][CH2:22][NH:23]C(=O)[O-])=[CH:13]1)(=[O:11])=[O:10].FC(F)(F)C(O)=O>C(Cl)Cl>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9]([N:12]1[C:20]2[CH:19]=[CH:18][N:17]=[CH:16][C:15]=2[C:14]([CH2:21][CH2:22][NH2:23])=[CH:13]1)(=[O:11])=[O:10]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22663080HCID 22663080, compound

Product 1

HCID 22663021HCID 22663021, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of {2-{1-[(2,4-difluorophenyl)sulfonyl]-1H-pyrrolo[3,2-c]pyridin-3-yl}ethyl}carbamate in CH2Cl2 is treated with trifluoroacetic acid, stirred for 2 h and concentrated in vacuo. The resultant residue is purified by preparative reverse phase HPLC to afford the title product.

Workup

  1. concentrationconcentrated in vacuo
  2. customThe resultant residue is purified by preparative reverse phase HPLC

Sources & evidence

ORD record
ord-ebfdb2d2adc348608140d03755ab848c
Source dataset
uspto-grants-2009_09
Patent number
US07585876B2

Reaction notes

Loading…