Trifluoroacetic acid → HCID 22663050, compound

HRID 731604Notes

Reaction equation

HRID 731604 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:9]([N:12]2[C:16]3=[CH:17][N:18]=[CH:19][CH:20]=[C:15]3[C:14]([CH2:21][CH2:22][NH:23]C(=O)OC(C)(C)C)=[CH:13]2)(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:9]([N:12]2[C:16]3=[CH:17][N:18]=[CH:19][CH:20]=[C:15]3[C:14]([CH2:21][CH2:22][NH2:23])=[CH:13]2)(=[O:10])=[O:11])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23521605HCID 23521605, compound

Product 1

HCID 22663050HCID 22663050, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of t-Butyl [2-{1-(3-methoxybenzene-sulfonyl)-1H-pyrrolo[2,3-c]pyridin-3-yl}-ethyl]carbamate in CH2Cl2 is treated with trifluoroacetic acid, stirred for 2 h and concentrated in vacuo. The resultant residue is purified by preparative reverse phase HPLC to afford the title final product.

Workup

  1. concentrationconcentrated in vacuo
  2. customThe resultant residue is purified by preparative reverse phase HPLC

Sources & evidence

ORD record
ord-4734c10193524effb7f1dbe3e961a111
Source dataset
uspto-grants-2009_09
Patent number
US07585876B2

Reaction notes

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