2-Amino-4-methylpyridine → HCID 24738342, compound

HRID 731615Notes

Reaction equation

HRID 731615 reaction equation
Br[CH2:2][C:3]([C:5]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:7][O:8][C:9]=1[CH3:10])=O.[NH2:17][C:18]1[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][N:19]=1>>[CH3:24][C:22]1[CH:21]=[CH:20][N:19]2[CH:2]=[C:3]([C:5]3[C:6]([C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=4)=[N:7][O:8][C:9]=3[CH3:10])[N:17]=[C:18]2[CH:23]=1

Participants

3

Reactant 2

HCID 15332-Amino-4-methylpyridineHCID 27355314-(Bromoacetyl)-5-methyl-3-phenylisoxazole

Product 1

HCID 24738342HCID 24738342, compoundYield 19%

Procedure

As described for Example 2, 4-(bromoacetyl)-5-methyl-3-phenylisoxazole (commercially available) (140 mg, 0.5 mmol) was converted, using 2-amino-4-methylpyridine instead of 2-amino-3-methylpyridine, to the title compound (22 mg, 19%) which was obtained as a yellow solid. MS: m/e=290.0 [M+H]+.

Sources & evidence

ORD record
ord-18664e352fd043a0a50225fdbdd51835
Source dataset
uspto-grants-2009_09
Patent number
US07585874B2

Reaction notes

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