Methyl 2-aminopyridine-4-carboxylate → HCID 24738344, compound

HRID 731617Notes

Reaction equation

HRID 731617 reaction equation
Br[CH2:2][C:3]([C:5]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:7][O:8][C:9]=1[CH3:10])=O.[NH2:17][C:18]1[CH:23]=[C:22]([C:24]([O:26][CH3:27])=[O:25])[CH:21]=[CH:20][N:19]=1>>[CH3:27][O:26][C:24]([C:22]1[CH:21]=[CH:20][N:19]2[CH:2]=[C:3]([C:5]3[C:6]([C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=4)=[N:7][O:8][C:9]=3[CH3:10])[N:17]=[C:18]2[CH:23]=1)=[O:25]

Participants

3

Reactant 2

HCID 236984Methyl 2-aminopyridine-4-carboxylateHCID 27355314-(Bromoacetyl)-5-methyl-3-phenylisoxazole

Product 1

HCID 24738344HCID 24738344, compoundYield 58%

Procedure

As described for Example 1, 4-(bromoacetyl)-5-methyl-3-phenylisoxazole (commercially available) (280 mg, 1.0 mmol) was converted, using methyl 2-aminopyridine-4-carboxylate instead of 2-aminopyridine, to the title compound (194 mg, 58%) which was obtained as a yellow foam. MS: m/e=334.1 [M+H]+.

Sources & evidence

ORD record
ord-2fd31f736cd34c17b4092ca035167a9d
Source dataset
uspto-grants-2009_09
Patent number
US07585874B2

Reaction notes

Loading…