Propargylamine → HCID 24738506, compound

HRID 731620Notes

Reaction equation

[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]1[N:14]=[C:15]2[CH:20]=[C:19]([C:21](O)=[O:22])[CH:18]=[CH:17][N:16]2[CH:24]=1.[CH2:25]([NH2:28])[C:26]#[CH:27]>>[CH2:25]([NH:28][C:21]([C:19]1[CH:18]=[CH:17][N:16]2[CH:24]=[C:13]([C:3]3[C:4]([C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=4)=[N:5][O:6][C:2]=3[CH3:1])[N:14]=[C:15]2[CH:20]=1)=[O:22])[C:26]#[CH:27]

Participants

Reactant 2

HCID 239041Propargylamine

HCID 69067892HCID 69067892, compound

Product 1

HCID 24738506HCID 24738506, compoundYield 63%

Procedure

As described for Example 11b, 2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridine-7-carboxylic acid (64 mg, 0.2 mmol) was converted, using propargylamine instead of aminomethylcyclopropane, to the title compound (45 mg, 63%) which was obtained as a white solid. MS: m/e=357.1 [M+H]+.

Sources & evidence

ORD record: ord-06cf6dd0e2cb4b86b1ec04c3966b6ffc
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07585874B2

Reaction notes

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