Cyclobutylamine → HCID 24738508, compound

HRID 731622Notes

Reaction equation

HRID 731622 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]1[N:14]=[C:15]2[CH:20]=[C:19]([C:21](O)=[O:22])[CH:18]=[CH:17][N:16]2[CH:24]=1.[CH:25]1([NH2:29])[CH2:28][CH2:27][CH2:26]1>>[CH:25]1([NH:29][C:21]([C:19]2[CH:18]=[CH:17][N:16]3[CH:24]=[C:13]([C:3]4[C:4]([C:7]5[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=5)=[N:5][O:6][C:2]=4[CH3:1])[N:14]=[C:15]3[CH:20]=2)=[O:22])[CH2:28][CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 75645CyclobutylamineHCID 69067892HCID 69067892, compound

Product 1

HCID 24738508HCID 24738508, compoundYield 80%

Procedure

As described for Example 11b, 2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridine-7-carboxylic acid (96 mg, 0.3 mmol) was converted, using cyclobutylamine instead of aminomethylcyclopropane, to the title compound (89 mg, 80%) which was obtained as a light yellow foam. MS: m/e=373.0 [M+H]+.

Sources & evidence

ORD record
ord-ba43585549e24e6783be3e1860bac172
Source dataset
uspto-grants-2009_09
Patent number
US07585874B2

Reaction notes

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