2-Morpholinoethylamine → HCID 24738673, compound

HRID 731626Notes

Reaction equation

[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]1[N:14]=[C:15]2[CH:20]=[C:19]([C:21](O)=[O:22])[CH:18]=[CH:17][N:16]2[CH:24]=1.[NH2:25][CH2:26][CH2:27][N:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>>[N:28]1([CH2:27][CH2:26][NH:25][C:21]([C:19]2[CH:18]=[CH:17][N:16]3[CH:24]=[C:13]([C:3]4[C:4]([C:7]5[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=5)=[N:5][O:6][C:2]=4[CH3:1])[N:14]=[C:15]3[CH:20]=2)=[O:22])[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1

Participants

Reactant 2

HCID 4082852-Morpholinoethylamine

HCID 69067892HCID 69067892, compound

Product 1

HCID 24738673HCID 24738673, compoundYield 48%

Procedure

As described for Example 11b, 2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridine-7-carboxylic acid (64 mg, 0.2 mmol) was converted, using N-(2-aminoethyl)morpholine instead of aminomethylcyclopropane, to the title compound (41 mg, 48%) which was obtained as a light yellow foam. MS: m/e=432.5 [M+H]+.

Sources & evidence

ORD record: ord-a5d9cadcce1b4cb8a2e4dbf15a718864
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07585874B2

Reaction notes

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