2-Amino-4-bromopyridine → HCID 24738828, compound

HRID 731641Notes

Reaction equation

HRID 731641 reaction equation
Br[CH2:2][C:3]([C:5]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:7][O:8][C:9]=1[CH3:10])=O.[NH2:17][C:18]1[CH:23]=[C:22]([Br:24])[CH:21]=[CH:20][N:19]=1>>[Br:24][C:22]1[CH:21]=[CH:20][N:19]2[CH:2]=[C:3]([C:5]3[C:6]([C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=4)=[N:7][O:8][C:9]=3[CH3:10])[N:17]=[C:18]2[CH:23]=1

Participants

3

Reactant 2

HCID 6932822-Amino-4-bromopyridineHCID 27355314-(Bromoacetyl)-5-methyl-3-phenylisoxazole

Product 1

HCID 24738828HCID 24738828, compoundYield 33%

Procedure

As described for Example 2, 4-(bromoacetyl)-5-methyl-3-phenylisoxazole (commercially available) (2.0 g, 7.2 mmol) was converted, using 2-amino-4-bromopyridine instead of 2-amino-3-methylpyridine, to the title compound (824 mg, 33%) which was obtained as a light yellow foam. MS: m/e=354.1/355.9 [M+H]+.

Sources & evidence

ORD record
ord-b6c0ffc1a63b4c718ae3196f7fc7fa65
Source dataset
uspto-grants-2009_09
Patent number
US07585874B2

Reaction notes

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