Pyrazole → HCID 24739642, compound

HRID 731662Notes

Reaction equation

HRID 731662 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[C:12]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)=[N:13][O:14][C:15]=3[CH3:16])[N:10]=2)[CH:7]=1.[NH:23]1[CH:27]=[CH:26][CH:25]=[N:24]1>>[CH3:16][C:15]1[O:14][N:13]=[C:12]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]=1[C:9]1[N:10]=[C:5]2[CH:4]=[CH:3][C:2]([N:23]3[CH:27]=[CH:26][CH:25]=[N:24]3)=[CH:7][N:6]2[CH:8]=1

Participants

3

Reactant 2

HCID 1048PyrazoleHCID 24738993HCID 24738993, compound

Product 1

HCID 24739642HCID 24739642, compoundYield 16%

Procedure

As described for Example 60, 6-bromo-2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridine (70.8 mg, 0.2 mmol) instead of 6-iodo-2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridine was converted, using pyrazole instead of benzamide, to the title compound (11 mg, 16%) which was obtained as a light yellow gum. MS: m/e=342.3 [M+H]+.

Sources & evidence

ORD record
ord-be4b68b8773249cab636df48b527113f
Source dataset
uspto-grants-2009_09
Patent number
US07585874B2

Reaction notes

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