反应详情

To a solution of 500 mg (2 mmol) 2-chloro-1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one in 4 ml of MeOH was added 227 mg (2.6 mmol) of morpholine and 150 mg NaI. The mixture was stirred at RT for 3 days. The solvent was removed and the residue dissolved in 5 ml of ether, followed by titration with 4N HCl-dioxane to obtain a precipitate. Recrystallization from isopropanol/ether produced 200 mg of pure 1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-morpholinopropan-1-one hydrochloride. Compound 1034.

1. customThe solvent was removed
2. dissolutionthe residue dissolved in 5 ml of ether
3. customto obtain a precipitate
4. customRecrystallization from isopropanol/ether