HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylbenzylamine → 2-(Benzyl(methyl)amino)-1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylbenzylamine | HCID 7669 | — |
| Reactant | 2-Chloro-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone | HCID 21585751 | — |
| Catalyst | Sodium Iodide | HCID 5238 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(Benzyl(methyl)amino)-1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one | HCID 57837514 | 33.4% |
Reaction Steps
A mixture of 2.37 g (13.4 mmol) of 2-chloro-1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one, 1.74 ml (13.4 mmol) of N-methyl benzylamine and 50 mg of NaI in 15 ml of MeOH was refluxed overnight. The mixture obtained after evaporation of the solvent was purified on an Al2O3 column, and recrystallized from ether/hexane to obtain 1.5 g of 2-(benzyl(methyl)amino)-1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one. Compound 1041.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585875B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-5fc9445f210a4892afe0d8271376d6b7 |
| Source note | uspto-grants-2009_09 |