HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → HCID 68549011, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 2-Chloro-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone | HCID 21585751 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 68549011 | HCID 68549011 | 54.8% |
Reaction Steps
621 mg (2.4 mmol) of 2-chloro-1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one was reacted with 283 mg (4.8 mmol) cyclopropylamine in the presence of 20 mg of NaI in 6 ml of MeOH. The crude product obtained after workup was acidified with 2N HCl-ether to furnish 405 mg of 2-(cyclopropylamino)-1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one hydrochloride. Compound 1045.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585875B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-939c581428fb45319e74e3d68bf7b2e9 |
| Source note | uspto-grants-2009_09 |