Sodium Iodide → HCID 68549011, compound

HRID 731719Notes

Reaction equation

HRID 731719 reaction equation
[Cl:1][CH:2]([CH3:17])[C:3]([C:5]1[C:6]([CH:14]([CH3:16])[CH3:15])=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=12)=[O:4].[CH:18]1([NH2:21])[CH2:20][CH2:19]1.[Na+].[I-]>CO>[ClH:1].[CH:18]1([NH:21][CH:2]([CH3:17])[C:3]([C:5]2[C:6]([CH:14]([CH3:16])[CH3:15])=[N:7][N:8]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=23)=[O:4])[CH2:20][CH2:19]1

Participants

5

Reactant 3

HCID 5238Sodium IodideHCID 69828CyclopropylamineHCID 215857512-Chloro-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone

Product 1

HCID 68549011HCID 68549011, compoundYield 54.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

621 mg (2.4 mmol) of 2-chloro-1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one was reacted with 283 mg (4.8 mmol) cyclopropylamine in the presence of 20 mg of NaI in 6 ml of MeOH. The crude product obtained after workup was acidified with 2N HCl-ether to furnish 405 mg of 2-(cyclopropylamino)-1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one hydrochloride. Compound 1045.

Workup

  1. customThe crude product obtained after workup

Sources & evidence

ORD record
ord-939c581428fb45319e74e3d68bf7b2e9
Source dataset
uspto-grants-2009_09
Patent number
US07585875B2

Reaction notes

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