Acetic Acid → HCID 57837445, compound

HRID 731726Notes

Reaction equation

HRID 731726 reaction equation
Cl[CH2:2][C:3]([C:5]1[C:6]([CH:14]([CH3:16])[CH3:15])=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=12)=O.[NH2:17][C:18]([NH2:20])=[S:19].CC(O)=O>O1CCOCC1>[CH:14]([C:6]1[C:5]([C:3]2[NH:17][C:18](=[S:19])[NH:20][CH:2]=2)=[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][N:8]2[N:7]=1)([CH3:16])[CH3:15]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 2723790ThioureaHCID 86637278HCID 86637278, compound

Product 1

HCID 57837445HCID 57837445, compoundYield 121%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 200 mg (0.63 mmol) of 2-chloro-1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)ethanone, 100 mg of thiourea and 100 μl of HOAc were stirred in 1.5 ml of dioxane at 60-700 C for 30 minutes. 197 mg of 4-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)-1H-imidazole-2(3H)-thione was obtained after workup. Compound 1085.

Sources & evidence

ORD record
ord-27f0fe1911254de59af8affa7f92dc82
Source dataset
uspto-grants-2009_09
Patent number
US07585875B2

Reaction notes

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