HCID 9954997, compound → HCID 178508713, compound

HRID 731871Notes

Reaction equation

HRID 731871 reaction equation
C([N:5]1[C:9]2=[N:10][CH:11]=[N:12][C:13]([NH2:14])=[C:8]2[C:7]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH2:22][C:23]3[C:28]([Cl:29])=[CH:27][CH:26]=[CH:25][C:24]=3[Cl:30])[CH:16]=2)=[N:6]1)(C)(C)C>C(O)=O.Cl>[Cl:29][C:28]1[CH:27]=[CH:26][CH:25]=[C:24]([Cl:30])[C:23]=1[CH2:22][O:21][C:17]1[CH:16]=[C:15]([C:7]2[C:8]3[C:9](=[N:10][CH:11]=[N:12][C:13]=3[NH2:14])[NH:5][N:6]=2)[CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 1

HCID 9954997HCID 9954997, compound

Product 1

HCID 178508713HCID 178508713, compound

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 313Hydrochloric AcidSolvent

Procedure

1-tert-butyl-3-(3-(2,6-dichlorobenzyloxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (19.5 mg, 0.05 mmol) was dissolved in a solution of formic acid (2 mL) and conc. HCl (0.2 mL) and heated to reflux for 30 min. Reaction was concentrated in vacuo and purified by RP-HPLC (MeCN:H2O:0.1% TFA). ESI-MS (M+H)+ m/z calcd 386.1, found 386.2.

Workup

  1. temperatureheated
  2. temperatureto reflux for 30 min
  3. customReaction
  4. concentrationwas concentrated in vacuo
  5. custompurified by RP-HPLC (MeCN:H2O:0.1% TFA)

Sources & evidence

ORD record
ord-4bd3420231f2415180bd8a4ccec4fa30
Source dataset
uspto-grants-2009_09
Patent number
US07585868B2

Reaction notes

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