HCID 68711548, compound → HCID 178508706, compound

HRID 731878Notes

Reaction equation

HRID 731878 reaction equation
C([N:5]1[C:9]2=[N:10][CH:11]=[N:12][C:13]([NH2:14])=[C:8]2[C:7]([CH:15]2[CH2:24][CH2:23][C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:16]2)=[N:6]1)(C)(C)C>C(O)=O.Cl>[CH2:16]1[C:17]2[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:23][CH2:24][CH:15]1[C:7]1[C:8]2[C:9](=[N:10][CH:11]=[N:12][C:13]=2[NH2:14])[NH:5][N:6]=1

Participants

4

Reactant 1

HCID 68711548HCID 68711548, compound

Product 1

HCID 178508706HCID 178508706, compound

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 313Hydrochloric AcidSolvent

Procedure

1-tert-butyl-3-(1,2,3,4-tetrahydronaphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (9 mg, 0.029 mmol) was dissolved in a solution of formic acid (1 mL) and conc. HCl (0.1 mL) and heated to reflux. The reaction was allowed to proceed 30 min., then concentrated in vacuo and the products purified by RP-HPLC (MeCN:H2O:0.1% TFA). ESI-MS (M+H)+ m/z calcd 266.1, found 266.4.

Workup

  1. temperatureheated to reflux
  2. concentrationconcentrated in vacuo
  3. customthe products purified by RP-HPLC (MeCN:H2O:0.1% TFA)

Sources & evidence

ORD record
ord-9dc764bda6c74e0c821c3ec4aefc010f
Source dataset
uspto-grants-2009_09
Patent number
US07585868B2

Reaction notes

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