1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine → HCID 178424072, compound

HRID 731880Notes

Reaction equation

HRID 731880 reaction equation
C([N:5]1[C:9]2=[N:10][CH:11]=[N:12][C:13]([NH2:14])=[C:8]2[C:7]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)=[N:6]1)(C)(C)C>C(O)=O.Cl>[C:18]1([CH3:21])[CH:17]=[CH:16][C:15]([C:7]2[C:8]3[C:9](=[N:10][CH:11]=[N:12][C:13]=3[NH2:14])[NH:5][N:6]=2)=[CH:20][CH:19]=1

Participants

4

Reactant 1

HCID 14001-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine

Product 1

HCID 178424072HCID 178424072, compound

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 313Hydrochloric AcidSolvent

Procedure

1-tert-butyl-3-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine was dissolved in a solution of formic acid (1 mL) and conc. HCl (0.1 mL) and heated to reflux. The reaction was allowed to proceed 30 min., then concentrated in vacuo and the products purified by RP-HPLC (MeCN:H2O:0.1% TFA). ESI-MS (M+H)+ m/z calcd 226.1, found 226.3.

Workup

  1. temperatureheated to reflux
  2. concentrationconcentrated in vacuo
  3. customthe products purified by RP-HPLC (MeCN:H2O:0.1% TFA)

Sources & evidence

ORD record
ord-e382d53025734e2caf6c2225b746cba3
Source dataset
uspto-grants-2009_09
Patent number
US07585868B2

Reaction notes

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