反应详情

In 100 ml of acetonitrile was dissolved 9.3 g of ethyl 2-(bromomethyl)biphenyl-4-carboxylate, and 7.0 g of N-methylmorpholine-N-oxide was added thereto at room temperature, followed by 4 hours of stirring. Water was added to the reaction solution, which was then extracted with ethyl acetate. The resulting organic layer was dried over anhydrous magnesium sulfate. After the solvent was removed by evaporation, the obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate) to obtain 4.94 g of ethyl 2-formylbiphenyl-4-carboxylate as a white solid.

1. additionwas added
2. extractionwas then extracted with ethyl acetate
3. dry with materialThe resulting organic layer was dried over anhydrous magnesium sulfate
4. customAfter the solvent was removed by evaporation
5. customthe obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate)