反应详情

In 50 ml of methylene chloride was dissolved 2.5 g of 6-nitroindoline, and then 6.37 ml of triethylamine was added thereto. Under ice cooling, 3.51 g of methanesulfonyl chloride was added dropwise, the reaction solution was stirred at room temperature for 3 hours, and then ice-water was added thereto, followed by 1 hour of stirring. The reaction solvent was removed by evaporation under reduced pressure, a 1M aqueous hydrochloric acid solution was added to the residue, and precipitated was filtrated off, whereby 3.52 g of 1-methylsulfonyl-6-nitroindoline was obtained as a brown solid.

1. waitfollowed by 1 hour
2. stirringof stirring
3. customThe reaction solvent was removed by evaporation under reduced pressure
4. additiona 1M aqueous hydrochloric acid solution was added to the residue
5. customprecipitated
6. filtrationwas filtrated off