Cyclopropyl isothiocyanate → HCID 57837972, compound

HRID 732092Notes

Reaction equation

HRID 732092 reaction equation
[CH:1]1([N:4]=[C:5]=[S:6])[CH2:3][CH2:2]1.[Cl:7][C:8]1[CH:9]=[C:10]([C:14]2[O:18][N:17]=[C:16]([CH2:19][NH:20][CH3:21])[N:15]=2)[CH:11]=[CH:12][CH:13]=1>CCO>[Cl:7][C:8]1[CH:9]=[C:10]([C:14]2[O:18][N:17]=[C:16]([CH2:19][N:20]([CH3:21])[C:5]([NH:4][CH:1]3[CH2:3][CH2:2]3)=[S:6])[N:15]=2)[CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 92463Cyclopropyl isothiocyanateHCID 57838010HCID 57838010, compound

Product 1

HCID 57837972HCID 57837972, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Cyclopropyl isothiocyanate (650 mg, 6.6 mmol) was added to 1-[5-(3-chlorophenyl)-[1,2,4]oxadiazol-3-yl]-N-methylmethanamine (1.47 g, 6.5 mmol) in EtOH (20 mL). After 3 h the formed precipitate was filtrated off and washed with cold EtOH to give 1.63 g (78%) of the title compound. LC-MS (M++1): 323.

Workup

  1. filtrationAfter 3 h the formed precipitate was filtrated off
  2. washwashed with cold EtOH

Sources & evidence

ORD record
ord-6db1747ed73c4ba18da90187e29c4f9d
Source dataset
uspto-grants-2009_09
Patent number
US07585881B2

Reaction notes

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