Water → HCID 57838014, compound

HRID 732097Notes

Reaction equation

HRID 732097 reaction equation
Cl.[C:2](Cl)(=O)[C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1.I.[CH:12]1([NH:15][C:16](=[N:19][NH2:20])[NH:17][CH3:18])[CH2:14][CH2:13]1.O>N1C=CC=CC=1>[CH:12]1([NH:15][C:16]2[N:17]([CH3:18])[C:2]([C:3]3[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=3)=[N:20][N:19]=2)[CH2:14][CH2:13]1

Participants

5

Reactant 3

HCID 962WaterHCID 12262826Isonicotinoyl chloride hydrochlorideHCID 178485176HCID 178485176, compound

Product 1

HCID 57838014HCID 57838014, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Isonicotinoyl chloride hydrochloride (630 mg, 3.5 mmol) was added to N-cyclopropyl-N′-methylcarbonohydrazonic diamide hydroiodide (900 mg 3.5 mmol) in pyridine (10 ml) and the mixture was stirred at r.t. for 2 h. The mixture was the heated to 160° C. under microwave irradiation for 10 min. Water (50 ml) was added and the mixture was extracted with DCM. The pooled organic phases were dried and concentrated and the desired product was obtained by prep. HPLC. LCMS (M++1) 216

Workup

  1. temperatureheated to 160° C. under microwave irradiation for 10 min
  2. extractionthe mixture was extracted with DCM
  3. customThe pooled organic phases were dried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-f2c73cb8a7044d44943fe00c9af797ca
Source dataset
uspto-grants-2009_09
Patent number
US07585881B2

Reaction notes

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