HRID732211

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID23082888

未命名化合物

结构：OCc1ccc(CN(CCc2ccccn2)c2nc(-c3ccccc3)cs2)cc1

HCID23143295

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)CCc1ccc(OCc2ccc(CN(CCc3ccccn3)c3nc(-c4ccccc4)cs3)cc2)cc1F

HCID23143320

未命名化合物

收率 41%

PROCEDURE

实验过程

The title compound was synthesized in the same manner as in Example 8 from (4-{[(4-phenyl-1,3-thiazol-2-yl)(2-pyridin-2-ylethyl)amino]methyl}phenyl)methanol and ethyl 3-(2-fluoro-4-hydroxyphenyl)propanoate by Mitsunobu reaction (yield 41%). Yellow oil.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e6aae06c69244b159fdeb88e579a78c8
来源数据集: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07585880B2
来源说明: uspto-grants-2009_09

反应 SMILES

[C:1]1([C:7]2[N:8]=[C:9]([N:12]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([CH2:28][OH:29])=[CH:24][CH:23]=3)[CH2:13][CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:30][C:31]1[CH:36]=[C:35](O)[CH:34]=[CH:33][C:32]=1[CH2:38][CH2:39][C:40]([O:42][CH2:43][CH3:44])=[O:41]>>[F:30][C:31]1[CH:36]=[C:35]([O:29][CH2:28][C:25]2[CH:24]=[CH:23][C:22]([CH2:21][N:12]([C:9]3[S:10][CH:11]=[C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[N:8]=3)[CH2:13][CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)=[CH:27][CH:26]=2)[CH:34]=[CH:33][C:32]=1[CH2:38][CH2:39][C:40]([O:42][CH2:43][CH3:44])=[O:41]