Ethyl 3-(2-fluoro-4-hydroxyphenyl)propanoate → HCID 23143320, compound

HRID 732211Notes

Reaction equation

HRID 732211 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([N:12]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([CH2:28][OH:29])=[CH:24][CH:23]=3)[CH2:13][CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:30][C:31]1[CH:36]=[C:35](O)[CH:34]=[CH:33][C:32]=1[CH2:38][CH2:39][C:40]([O:42][CH2:43][CH3:44])=[O:41]>>[F:30][C:31]1[CH:36]=[C:35]([O:29][CH2:28][C:25]2[CH:24]=[CH:23][C:22]([CH2:21][N:12]([C:9]3[S:10][CH:11]=[C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[N:8]=3)[CH2:13][CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)=[CH:27][CH:26]=2)[CH:34]=[CH:33][C:32]=1[CH2:38][CH2:39][C:40]([O:42][CH2:43][CH3:44])=[O:41]

Participants

3

Reactant 2

HCID 23082888Ethyl 3-(2-fluoro-4-hydroxyphenyl)propanoateHCID 23143295(4-([(4-Phenyl-1,3-thiazol-2-yl)(2-pyridin-2-ylethyl)amino]methyl}phenyl)methanol

Product 1

HCID 23143320HCID 23143320, compoundYield 41%

Procedure

The title compound was synthesized in the same manner as in Example 8 from (4-{[(4-phenyl-1,3-thiazol-2-yl)(2-pyridin-2-ylethyl)amino]methyl}phenyl)methanol and ethyl 3-(2-fluoro-4-hydroxyphenyl)propanoate by Mitsunobu reaction (yield 41%). Yellow oil.

Sources & evidence

ORD record
ord-e6aae06c69244b159fdeb88e579a78c8
Source dataset
uspto-grants-2009_09
Patent number
US07585880B2

Reaction notes

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