HCID 86600459, compound → 3-Phenylprop-2-enoyl chloride

HRID 732260Notes

Reaction equation

HRID 732260 reaction equation
N1CC1.[C:4]([Cl:14])(=[O:13])[CH:5]=[CH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C(O)(=O)C>[C:4]([Cl:14])(=[O:13])[CH:5]=[CH:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

3

Reactant 1

HCID 86600459HCID 86600459, compound

Product 1

HCID 660233-Phenylprop-2-enoyl chloride

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

As further shown in FIG. 3, the cinnamoyl chloride aziridine intermediate was dissolved in aqueous acetic acid at 0° C., stirred at this temperature for 10 h and worked up as usual. Purification of the crude mixture by column chromatography and crystallization afforded the open chain cinnamoyl chloride intermediate.

Workup

  1. customPurification of the crude mixture
  2. customby column chromatography and crystallization

Sources & evidence

ORD record
ord-b617d0d5d762468ea81aa41c201e3b0c
Source dataset
uspto-grants-2009_09
Patent number
US07585986B2

Reaction notes

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