HRID732344

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1ccccc1CN(Cc1ccccc1C)[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)c1cccn1C(=O)OC(C)(C)C

HCID68814650

未命名化合物

HCID178418361

未命名化合物

PRODUCTS

生成物

结构：Cc1ccccc1CN(Cc1ccccc1C)[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1CCCN1C(=O)OC(C)(C)C

HCID68814606

未命名化合物

收率 28%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23939

Platinum

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Add 2-[2-(S)-[bis-(2-methylbenzyl)-amino]-3-(3,5-difluorophenyl)-1-(S)-hydroxypropyl]-pyrrole-1-carboxylic acid tert-butyl ester (0.415 g, 0.74 mmol), 10% platinum on carbon (0.087 g) and methanol (15 mL) and hydrogenate at one atmosphere hydrogen gas for 1-8 h. Add filter agent and filter, concentrate and purify (silica gel chromatography, eluting with hexanes and ethyl acetate) to give the title compound as a white foam (0.116 g, 28%).

WORKUP

后处理

additionAdd
filtrationfilter agent
filtrationfilter
concentrationconcentrate
custompurify
wash(silica gel chromatography, eluting with hexanes and ethyl acetate)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e1f93f575e8d4a6ea6da3d7fe7fbff71
来源数据集: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07585885B2
来源说明: uspto-grants-2009_09

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[C@@H:13]([OH:41])[C@@H:14]([N:24]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=1[CH3:40])[CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[CH3:32])[CH2:15][C:16]1[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([F:23])[CH:17]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>[Pt].CO>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[C@@H:13]([OH:41])[C@@H:14]([N:24]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=1[CH3:40])[CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[CH3:32])[CH2:15][C:16]1[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([F:23])[CH:17]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]