huagongshe.com
HRID732348

反应详情

EQUATION

反应方程式

HRID 732348 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)N1CCC[C@@H]1[C@@H](O)[C@H](Cc1ccccc1)N(Cc1ccccc1)Cc1ccccc1
HCID58699983

未命名化合物

结构：[H][H]
HCID178418361

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCC[C@@H]1[C@@H](O)[C@@H](N)Cc1ccccc1
HCID67456206

未命名化合物

收率 94.3%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[OH-].[OH-].[Pd+2]
催化剂HCID9942167

Palladium hydroxide

H2O2Pd

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Dissolve 2-(R)-(2-(S)-dibenzylamino-1-(S)-hydroxy-3-phenylpropyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (0.75 g, 1.49 mmol) in methanol (20 mL). Add 20% palladium hydroxide on carbon (0.33 g) and stir 1 h under one atmosphere of hydrogen gas. Filter through filter agent and concentrate to give the title compound as a white foam (0.45 g, 93%).

WORKUP

后处理

  1. filtrationFilter
  2. filtrationthrough filter agent
  3. concentrationconcentrate