反应详情

Dissolve (S)-2-sec-butylamino-6-cyano-isonicotinic acid methyl ester (250 mg, 0.93 mmol) in methanol (3 mL). Slowly add 2 N NaOH (1.5 mL) and stir overnight at room temperature. Acidify to about pH=6 with 5 N HCl and concentrate. Dilute with ethyl acetate (20 mL) and wash the organic layer with saturated aqueous sodium chloride, dry (magnesium sulfate) and concentrate to give the title compound.

1. concentrationconcentrate
2. additionDilute with ethyl acetate (20 mL)
3. washwash the organic layer with saturated aqueous sodium chloride
4. dry with materialdry (magnesium sulfate)
5. concentrationconcentrate