Trifluoroacetic acid → HCID 68814419, compound

HRID 732424Notes

Reaction equation

HRID 732424 reaction equation
FC(F)(F)C(O)=O.C([O:12][C:13](=[O:30])[C:14]1[CH:19]=[C:18]([S:20]([CH:23]2[CH2:25][CH2:24]2)(=[O:22])=[O:21])[N:17]=[C:16]([NH:26][CH:27]2[CH2:29][CH2:28]2)[CH:15]=1)(C)(C)C>ClCCl>[CH:27]1([NH:26][C:16]2[CH:15]=[C:14]([CH:19]=[C:18]([S:20]([CH:23]3[CH2:24][CH2:25]3)(=[O:22])=[O:21])[N:17]=2)[C:13]([OH:30])=[O:12])[CH2:28][CH2:29]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68814257HCID 68814257, compound

Product 1

HCID 68814419HCID 68814419, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Add trifluoroacetic acid (2 mL) to a solution of 2-cyclopropylamino-6-cyclopropanesulfonyl-isonicotinic acid tert-butyl ester (0.120 g, 0.355 mmol) in dichloromethane (2 mL) at 0° C. Stir the solution at room temperature for 3 h, concentrate and dry the title compound (0.076 g, 54%).

Workup

  1. concentrationconcentrate
  2. dry with materialdry the title compound (0.076 g, 54%)

Sources & evidence

ORD record
ord-ea52b4fedee240edafb28d08b2c0d546
Source dataset
uspto-grants-2009_09
Patent number
US07585885B2

Reaction notes

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