反应详情

温度

70 °C

Treat an ethanol suspension of 2-chloro-6-methoxy-isonicotinic acid (3.75 g, 20 mmol) at 0° C. with thionyl chloride for 30 min. Heat at 70° C. overnight. Cool to room temperature, concentrate, dissolve the residue in ethyl acetate (200 mL), wash the organic layer with saturated aqueous sodium bicarbonate solution, saturated aqueous sodium chloride solution, dry (magnesium sulfate) and concentrate to give the title compound (4.2 g, 98%).

1. additionTreat
2. temperatureCool to room temperature
3. concentrationconcentrate
4. dissolutiondissolve the residue in ethyl acetate (200 mL)
5. washwash the organic layer with saturated aqueous sodium bicarbonate solution, saturated aqueous sodium chloride solution
6. dry with materialdry (magnesium sulfate)
7. concentrationconcentrate