HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 732452Generated: October 29, 2026
Ethanol → Ethyl 2-chloro-6-methoxyisonicotinate
https://huagongshe.com/reaction/732452
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Chloro-6-methoxypyridine-4-carboxylic acid | HCID 2782124 | — |
| Product | Ethyl 2-chloro-6-methoxyisonicotinate | HCID 13611989 | 98% |
Reaction Steps
Treat an ethanol suspension of 2-chloro-6-methoxy-isonicotinic acid (3.75 g, 20 mmol) at 0° C. with thionyl chloride for 30 min. Heat at 70° C. overnight. Cool to room temperature, concentrate, dissolve the residue in ethyl acetate (200 mL), wash the organic layer with saturated aqueous sodium bicarbonate solution, saturated aqueous sodium chloride solution, dry (magnesium sulfate) and concentrate to give the title compound (4.2 g, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07585885B2 |
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| Source dataset | uspto-grants-2009_09 |
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| ORD ID | ord-a76f3d3fe3ea482eab15a4540b5befc3 |
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| Source note | uspto-grants-2009_09 |
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