HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (S)-2-sec-Butylamino-6-difluoromethoxy-isonicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (S)-2-sec-Butylamino-6-difluoromethoxy-isonicotinic acid ethyl ester | HCID 68814656 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (S)-2-sec-Butylamino-6-difluoromethoxy-isonicotinic acid | HCID 68815507 | 85% |
Reaction Steps
Add 2 N NaOH (0.67 mL) to (S)-2-sec-butylamino-6-difluoromethoxy-isonicotinic acid ethyl ester in ethanol (5 mL). Stir 3 h and acidify to about pH=4 with 1 N HCl and extract with ethyl acetate. Wash organic layer with saturated aqueous sodium chloride, dry (magnesium sulfate) and concentrate to give the title compound (0.1 g, 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585885B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-54a4f06812ab46a59319e68fac5aff4c |
| Source note | uspto-grants-2009_09 |